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by Olivier De Bardonneche last modified 27-03-2007 22:44


COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH



BIOPREDIC international is a leading provider of in vitro assay systems for drug discovery and drug development. The company, founded in 1993, now has 30 people, including 6 PhDs, and produces primary cells for toxicology and pharmacology, such as hepatocytes, keratinocytes and lymphocytes. The unit has extensive experience in cell culture and production (human and animal), cryopreservation and storage, functional controls, culture and use for drug metabolism or toxicity. It developed and distributed various cell models in the area of metabolism, transport and toxicity, and was involved in several interlaboratory studies for method validation. The company has already participated in two other EU programs.


Dr Christophe Chesné (CEO since 1993); expertise in drug metabolism and in vitro cell systems. Dr Nathalie Rougier (Chief of Research and Development department); expertise in cell biology. Dr Sylvie Rumin (researcher and manager), administration of Research and Development department. Sandrine Camus (engineer), quality control chief; background in cell primary culture.

Recent publications

1. P.Gripon et al. Infection of a human hepatoma cell line by hepatitis B virus. PNAS, 99, 15655-15660, 2002. 2. I. Girault et al. Real time RT-PCR measurement of the whole set of human CYPs involved in drug metabolism.. Drug Metab Dispos 2005 in press. 3. Casati S et al. Dendritic cells as a tool for the predictive identification of skin sensitization hazard. The report and Recommendations of ECVAM Workshop 51. Alt Lab Anim 2005. 4. Cabillic F et al. Hepatic environment elicits monocyte differentiation into a dendritic cell subset directing Th2 response. J Hepatol 2005 in press. 5. Hoogenboom L.A.P. et al. (2001). Genotoxicity testing of extracts from aflatoxin-contaminated peanut meal, following chemical decontamination. Food Add. Contam. 18, 329-341.

COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH
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EU funded project