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by Olivier De Bardonneche last modified 27-03-2007 22:43

Chiron, Trondheim

COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH



Chiron AS is a synthesis company, specializing in the preparation of sophisticated standards for chemical and biological analysis and in the development of chiral drug intermediates. Chiron has for a long time been working on the synthesis of standards of mutagenic substances like PAHs and similar products. Chiron’s role in the consortium is to design and synthesize agents that will induce damage in DNA, and to synthesize standards and internal standards for the comet assay.


Senior Scientists involved

Jon Eigill Johansen. Ph.D established Chiron in 1983. Interests: Biomarkers for geochemical and bioorganic analysis, natural product synthesis and isolation, chiral synthesis.Huiling Liu. Ph.D (research manager at Chiron from 2001; research interests in biocatalysis, enzymatic chemistry, peptide synthesis, synthesis of enantiopure compounds.

Eirik Sundby, PhD (Research scientist) Research interests: biocatalysis, synthesis of chiral compounds, enzymatic synthesis of PCB and PAH-glucuronides.

Recent publications

1. Sundby, E. et al. Synthesis of (+)-goniothalamin and its enantiomer by combination of lipase catalyzed resolution and alkene metathesis, Tetrahedron, 60, 521-524, 2004. 2 Lutnæs, BF et al. Characterization of Monofluorinated Polycyclic Aromatic Compounds by 1H, 13C and 19F NMR Spectroscopy. Magn. Reson. Chem (2005) 43, 588-594. 3. Østby, L. et al. Evaluation of CYP1A protein induction, biotransformation capacity and DNA adduct formation in a rat hepatoma cell line (Fao), as biomarkers of organic contamination in environmental soil samples. 2005, Accepted for publication in Water, Air and Soil Pollution.

Patent: Liu, H, et al. Kongenere, chlorierte, bromierte und/oder iodierte, fluorierte, aromatische Verbindungen mit zwei Benzolringen in ihrer Grundstruktur, Verfahren zu ihrer Herstellung und ihre Verwendung. German patent application 2004.

COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH
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EU funded project