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by Olivier De Bardonneche last modified 27-03-2007 22:42
COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH



Norwegian Institute of Public Health, financed by the Ministry of Health, has a central role in the national public health system, providing expert advice and performing experimental and population based research. The Registered Toxicologists of Department of Chemical Toxicology are active in EU and international activities related to regulation and classification of chemicals. The Department’s chief scientist Gunnar Brunborg has 20 years of experience in experimental cellular and organ toxicology, with emphasis in recent years on DNA lesion detection and DNA repair in germ cells of the male. Methodological issues and high-throughput methods including microarray based toxicogenomics have lately been in focus. Brunborg has experience from research projects financed by the EC 4th, 5th and 6th Framework Programmes

Scientific personnel


Erik J. Soderlund PhD, Nur Duale MSc, Ann-Karin Olsen PhD, Richard Wiger PhD, Ashild Andreassen PhD, Christine Bjorge PhD, Birgitte Lindeman PhD.

Recent publications

1. Jansen J. et al., Nucleotide excision repair in rat male germ cells: Low level of repair in intact cells contrasts with high dual incision activity in vitro. Nucleic Acids Res. 29: 1791-1800, 2001.

2. Olsen A.-K. et al., Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells. Nucleic Acids Res. 31: 1-13, 2003. 3. Skotheim, R. I. et al., Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res 65, 5588-5598, 2005. 4. Olsen, A. K. et al., How do male germ cells handle DNA damage? Toxicol Appl Pharmacol., 207:521-31, 2005. 5. Labaj J. et al., Analysis of DNA damage induced by pesticide 1,2-dibromo-3-chloropropane (DBCP) in rat testicular cells. Neoplasma, in press.

COMET ASSAY and CELL ARRAY for genotoxicity testing - non-animal alternative for REACH
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